Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Clinical Trials for Menopause - WrongDiagnosis.com Clinical Trials data for Menopause is grouped into the following categories:-. View by trial name. View by drugs used in Menopause clinical trials Dr. Susan Love Research Foundation | Menopause & Women's Health Menopause & Women's Health - Clinical Trials. Dr. Susan Love Research Foundation provides comprehensive information about breast cancer, menopause, Menopause Clinical Resources Clinical Resources by Topic: Gynecology. Menopause Clinical Resources. Pathology | Alternative/Complementary | Clinical Guidelines | Clinical Trials | News Clinical trial of new Bionovo menopause drug moves forward Today, millions of women suffer from often-harsh symptoms of menopause such as hot flashes and night sweats -- and relief is nowhere to be found. Center for Menopause, Hormonal Disorders and Women's Health CLINICAL TRIALS. ACTIVE TRIALS:. OSTEOPOROSIS TREATMENT TRIAL - participate in a MENOPAUSE - VGEF study - This study investigates the effect of estrogen Menopause Treatment and Symptoms trials Menopause Clinical Trials. Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin ClinicalTrials.gov Identifier: NCT00412269 - Active Obstetrics, Gynecology & Reproductive Sciences at Yale School of Clinical Trials. Trials by Disease. Women's Reproductive Cancers: Infertility; Menopause/Hormone Replacement Therapy (HRT); Pregnancy - Preterm Delivery Menopause Clinical Resources Clinical Resources by Topic: Gynecology. Menopause Clinical Resources. Clinical Guidelines | Clinical Trials | News | Miscellaneous Resources Clinical Trials at the University of Virginia Health System Clinical trials newly opened for enrollment since 19-Dec-2007. women's health issues including breast disorders, menopause, reproduction and more. Menopause Clinical Trials Listings and Information at Menopause Clinical Trials Listings and Information at ClinicalTrialsSearch.org. Menopause Clinical Trials - Find Clinical Trials information on Find Menopause Clinical Trials information here. CenterWatch Listing of Clinical Research Trials for Menopause Menopause Clinical Trials - Find Clinical Trials information on The National Institute of Mental Health is seeking patients with Menopause to receive a diagnostic evaluation and/or treatment as part of a clinical Clinical Trials Links to information about clinical trials, including randomised controlled trials Topics such as menopause, pregnancy, ageing, going into hospital Herbal treatment in the Menopause The treatment of the symptoms of menopause by herbal medicine has a long history of A number of controlled clinical trials have supported this claim, Menopause: Clinical Trials Case Western Reserve University. About Clinical Trials at University Hospitals Case Article Menopause: Clinical Trials ClinicalTrials.gov Disease Category Listing (181): Menopause San Antonio; Radiant Research - San Antonio Menopause Isnâ™t it Time to Talk to a Doctor? Back to Clinical Trials by Medical Areas. Research centers Search of: menopause - List Results - ClinicalTrials.gov 33, Completed, Clinical Trial to Evaluate the Efficacy and Safety of Org 50081 in the Treatment of Vasomotor Symptoms. Condition:, Menopause Bioidentical 'Natural' Hormone Evaluation in Early Menopause The purpose of this study is to try to gather early information about safety when "natural" or bioidentical hormones are used during early menopause. Disease Category Listing (171): Hormone Replacement Therapy: Menopause CenterWatch Listing of Clinical Research Trials for Hormone Replacement Therapy: Menopause. Clinical Trials: Hormone Replacement Therapy: Menopause |
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