Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Postgraduate Medicine: Weight gain during menopause Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 1991;40(12):1323-6; Gambacciani M, INFLUENCE OF YEARS SINCE MENOPAUSE ON BONE MINERAL METABOLISM IN Effects of age and menopause on bone mineral. density evaluated by biochemical markers of bone. metabolism. Nippon Eiseigaku Zasshi 1994;49:807 Menopause and Weight Gain at Menopause The top medical experts answer your questions about menopause Ask The Experts A change in body composition can also affect metabolism. Bone Mineral Density and Metabolism at an Early Stage of Menopause Conclusions: The present study showed that the negative effects of estrogen deficiency on BMD and bone metabolism in early menopause occurred independently Influence of years since menopause on bone mineral metabolism in Effects of age and menopause on bone mineral density evaluated by biochemical markers of bone metabolism. Nippon Eiseigaku Zasshi 1994;49:807-15. Subcutaneous Adipose Tissue Metabolism at Menopause: Importance of The aim of this study was to examine the contribution of menopause per se on sc adipose tissue (AT) metabolism in 16 women classified on the basis of their Influence of the presence of hot flashes during menopause on the BACKGROUND: To asses if the hot flushes during the menopause are associated to alterations in the metabolism of nitric oxide, total antioxidant activity and Thyroid Disease and Menopause / Thyroid Disease Information Source Menopause happens when a woman's ovaries run out of viable eggs, First, thyroid hormones regulate metabolism, which is often mistakenly thought of as Womens HealthCare Forum: Menopause The bodyâ™s metabolism changes during and after menopause. Everyoneâ™s metabolism begins to slow during the early-to mid-30s. This change occurs slowly, Trends in Endocrinology and Metabolism : Menopause â“ a new Although many books and articles have been written on the clinical management of the menopause, few, if any, can claim to act as a reference for everything Science Links Japan | Effect of Menopause on Bone Metabolism Effect of Menopause on Bone Metabolism Indices and Bone Mineral Density. Study of the Usefulness of Bone Metabolism Indices. CiNii - Impact of Menopause on Lipid and Bone Metabolism and Conclusion: We provided the natural changes of lipid and bone metabolism after menopause and how extent an estrogen replacement can reset these changes. Nature Clinical Practice Endocrinology & Metabolism | Herbal Nature Clinical Practice Endocrinology & Metabolism (2007) 3, 322 doi :10.1038/ncpendmet0439. Herbal menopause remedies are no more effective than placebo Weight Loss & Control During Menopause How to control your weight, during menopause. In a nutshell, weight control in menopause in best achieved, as follows:. Eat fewer calories Metabolism slows Symptoms of menopause In the process of menopause your metabolism slows down and your lean mass is decreasing and you start to build fat. Because muscle cells burn more calories Metabolism or menopause? Many women over age 40 experience hot flashes, fatigue or changes in their menstrual cycles. For many women, though, these are actually signs of thyroid Estrogen Metabolism, Menopause, and Health Outcomes, Maryfran R Estrogen Metabolism, Menopause, and Health Outcomes. Investigators: Maryfran R. Sowers, Daniel S. McConnell, Trivellore Raghunathan, John F. Randolph Jr Menopause and weight gain - Better Health Channel. With ageing, muscles decrease in bulk and the metabolism slows down. These changes can contribute to weight gain around the time of menopause. Weight gain after menopause: Reverse the middle age spread - CNN.com The most effective approach to reversing weight gain after menopause includes a Aerobic exercise boosts your metabolism and helps you burn fat. |
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