Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Surgical Menopause, Estrogen, and Cognitive Function in Women In addition to its ability to effect direct genomic actions, estrogen can also . less cognitive decline in elderly women who initiated ET at menopause, Surgical Menopause, Estrogen, and Cognitive Function in Women trogens were given to older women years after their surgical menopause. . mild cognitive impairment (MCI) and global cognitive abilities. In the E- Memory after menopause: preliminary considerations of hormone hormone therapy (HT) as a therapeutic imperative. by medical practitioners, to assist the maintenance of. cognitive abilities during and after the menopause Loss of Estrogen Affects Different Cognitive Abilities in Rhesus Second, aged female rhesus monkeys experience menopause. are capable of complex cognitive behaviors, such as short-term memory and spatial ability." Menopause - Fulltext: Volume 13(1) January/February 2006 p 19-27 We investigated whether menopause status and menopause age were associated with general cognitive ability, verbal memory, and visual search speed and MRC Unit for Lifelong Health and Ageing & MRC National Survey of Hatch S, Jones PB, Kuh D, Hardy RJ, Wadsworth MEJ, Richards M. Childhood cognitive ability and adult mental health in the British 1946 birth cohort. news reports for September 2003 The report appeared in the September issue of Menopause. Full reference . Cognitive abilities are fairly stable and may be correlated with longevity Maturitas : Age at natural menopause and cognition - Published by An economical model was specified to account for associations among childhood IQ, the timing of natural menopause, and diverse measures of cognitive ability Thinking straight: oestrogen and cognitive function at midlife Early studies suggest that taking oestrogen after menopause further increases Some women who take oestrogen and find that their cognitive abilities and Menopause - Fulltext: Volume 12(4) July/August 2005 p 475-482 Childhood cognitive ability and age at menopause: evidence from two cohort . An effect of cognitive ability on age at menopause was still observed to age |
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