Study Finds Menopause Symptoms Can Be Predicted

The number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.

Researchers now say they may be able to predict when that clock will wind down.

And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left.

According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason.

Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction.

"If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments."

Others reiterate, however, that the findings should be treated with caution.

"Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life."

According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000.

The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold.

The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause.

The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct.

While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated.

The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40.

SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction

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References: Resisting Disease and Constructing Experience
1990 "Changing Ideas: The Medicalization of Menopause." In The Meanings of Menopause: Historical, Medical and Clinical Perspectives. R. Formanek, ed. pp.

Part 1.2 of Resisting Disease and Constructing Experience
To evaluate the current extent of the medicalization of menopause, The third level of medicalization is technology. For menopause, the only medical

Politics, Ideology, and Medicine THE MEDICALIZATION OF MENOPAUSE
medicalized menopause continue to promote the use of estrogen for primary .. Medicalized menopause results in further medicalization of womenÁ™s lives.

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(2000) Leidy L, Canali C, Callahan W. The medicalization of menopause: implications for recruitment of study participants. Menopause, 7(3):193-199.

Changing ideas: the medicalization of menopause.
Exploring the medicalization of menopause illuminates some of the special and complicated ways that women's experiences are vulnerable to medical control.

JSTOR: Commentary on "Blood and Nerves Revisited: Menopause and
Instead, she argues that any explanation of the amazingly rapid medicalization of menopause in this Newfoundland community must go beyond standard medicine-

JSTOR: Encounters with Aging: Mythologies of Menopause in Japan
Encounters with Aging: Mythologies of Menopause in Japan and North America challenges not only North American physicians' medicalization of menopause,

The Medicalization of Menopause
The last decade has seen an accumulated medicalization of menopause from a natural stage of a woman's life to an 'ailment' or 'disease' requiring a

Rewriting menopause: Challenging the medical paradigm to reflect
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By examining the language and medical framework that surrounds the current medical discourse on menopause, we show that the medicalization of menopause

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Finally, the pharmaceutical industry must be recognized as a driving force in the medicalization of menopause. Many studies on hormones have been sponsored

Changing ideas: the medicalization of menopause.
This paper examines the intellectual roots of the medicalization of menopause in the 1930s and 1940s. An analysis of published papers written by prominent

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History of the medicalization of menopause. Is menopause medicalized? . Medicalizing menopause defines the bodies of midlife and older women as deficient

Addressing Postmenopausal Estrogen Deficiency
Medicalization of the menopause was under way.18 However, since almost nothing was Simultaneous with medicalization of the menopause, the concept that

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Studies of the medicalization of menopause, for example, Evidence of the conceptual medicalization of menopause can be found in

Dr. Art Hister á» 2005 á» March
Besides declaring that we should stop ÁœmedicalizingÁ« menopause and declaring that thereÁ™s no evidence for the effectiveness or safety of herbal therapies or

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Other menopause scholars relate the concept of medicalization to gender . associated with the medicalization of menopause a brief historical discussion

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The Medicalization. of. the Menopause. LILA E. NACHTIGALL in the United States will live half of their lives after the menopause. Therefore,


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