Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
| late menarche early menopause |
|
What's Hot: Diabetes and Menopause Thus the observed 6-year reduction in childbearing years, caused by late menarche and early menopause, clearly illustrates the significant decrease in the Maturitas : The influence of Nos3 polymorphisms on age at menarche Underlying processes leading to the phenomenon of early menopause have not yet Nos3 deficiency has been reported to be associated with late menarche, Epidemiology early menopause are sub-analyses of the one association, and. late menarche in early menopause is essentially a categorical. measure of time from menarche Science Links Japan | Relationships of Age at Menarche and Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. O S T E P R S S RISK PROFILE PERI- POSTMENOPAUSAL WOMEN ATTENDING The occurrence of late menarche (3 15 years) and short fertile period Older age at menarche,. early menopause, and consequently a decreased fertile Relationships of Age at Menarche and Menopause, and Reproductive menopause, and type of menopause. 15. Late menarche was defined. as the age at menarche ≥17 years and early menopause was. defined as the age at menopause SECULAR TREND AND INTRAPOPULATIONAL VARIATION IN AGE AT MENOPAUSE women with early and late menopause. Table 2. Distribution of age groups of women of early and late menarche and. menopause (women >55 years, Ovarian function and disease risk -- VECCHIA 4 (1): 65 -- The The risk of breast cancer is increased by early menarche, late menopause and regular menstrual cycles. The associations observed are modest, but are still Health 24 - Menopause, Age and menopause Cigarette smoking; Living in places of high altitude; History of having a mother with early menopause; Late menarche (having started late with the first Age at onset of menopause Late menarche not necessarily predictive of early menopause, Hence I do not agree with a statement by the American Dr. E. B. Lowry, M.D., who says: âœAs a Factors related to late menopause and early menarche as risk To investigate underlying factors of late menopause and early menarche which are regarded as risk factors for breast cancer, we analyzed the relationships |
| late menarche early menopause |
|
list perimenopause symptom early stages of menopause hysterectomy menopause symptom chills cream natural postmenopause progesterone |