Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Why Women Change | Human Evolution | DISCOVER Magazine Why are human females hobbled in their prime by menopause? The third and last objection acknowledges human menopause as an ancient phenomenon that is Amazon.com: Menopause: A Biocultural Perspective (Studies in Menopause is a biological reality for all women in their forties and fifties. human menopause, climacteric scale, menopause transition, Patent 6583334 Title: Ovariectomized mouse model for human menopause. United States Patent: 6583334. Issued: June 24, 2003. Inventors: Haslam; Sandra Z. (Laingsburg, MI) Short communication: seasonal onset of menopause? -- Garai et al 2004 by European Society of Human Reproduction and Embryology Key words: equinox/human menopause/menstrual cycle/seasonal change Nonhuman Primate Models of Menopause Workshop -- Bellino and Wise Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, Archive: Theorists See Evolutionary Advantages In Menopause Dr. George C. Williams, a renowned evolutionary biologist, first proposed it in 1957 to explain the seemingly anomalous nature of human menopause. facial pain of dental disease, The totality of being human ,Menopause Menopause is a universal biological event in the life of women that occurs at a mean age of 51.8 years and marks the transition from the reproductive to the Menopause - Abstract: Volume 1(4) Winter 1994 p 211-222 How Did Both an anxious public and a concerned medical profession wonder about the human menopause: essentially, is it normal or abnormal? Ovariectomized mouse model for human menopause - US Patent 6583334 Ovariectomized mouse model for human menopause - US Patent 6583334 from Patent Storm. A method for determining a response to a biologically active agent in Evolution of the human menopause Despite half a century of enquiry, the human menopause. remains an evolutionary puzzle. (1). Fertility loss in women. (menopause) occurs at a remarkably Evolution of the human menopause. Several theories have been proposed to explain why menopause might have evolved, all based on unusual aspects of the human life history. Packer and colleagues model of menopause for humans evant to understanding the evolution of human menopause. Following expected; and (2) human menopause takes place long before other body Unlike humans, chimpanzees don't go through menopause | Science Blog Human menopause is remarkable in that reproductive deterioration is markedly accelerated relative to the aging of the rest of the body, leaving an extended IngentaConnect Human menopause delay Human menopause delay. Source: Reproductive BioMedicine Online, Volume 1, Number 3, December 2000, pp. 122-123(2). Publisher: Reproductive Healthcare Ltd Ovariectomized mouse model for human menopause - Patent 6583334 A method for determining a response to a biologically active agent in ovariectomized lower test mammals is described. The mammals are divided into those IngentaConnect Human menopause delay Human menopause delay. Source: Reproductive BioMedicine Online, Volume 1, Number 3, download Human menopause delay. Back to top. Key:. Free Content A New Hormonally Relevant Model for Human Menopause - The Jackson Finding an appropriate model for human menopause has been difficult for several reasons. Non-human primates experience human-like menopause, but menopause Novel Mouse Model of Human Menopause Available Soon at Bar Harbo JAX ^ Services offers our novel menopause mouse model (formerly available only through JAX ^ West, Sacramento, Calif.) from our Bar Harbor, Maine facility. The Thinking Meat Project / Human menopause unusual among primates Human menopause unusual among primates. Some recent research indicates that chimpanzees, our closest genetic relatives, do not go through menopause as |
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