Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Menopause: What to Expect When Your Body is Changing This is one of the first signs of menopause. You may skip periods or they may occur closer together. Your flow may be lighter or heavier than usual. SYMPTOMS Worst, this sign often shows up early in menopause. Like bone loss, which occurs rapidly in the first few years of menopause, collagen loss is most rapid at Menopause: Signs and Symptoms of Menopause The first stage of menopause is known as perimenopause. The first signs of menopause are irregular periods and spotting due to fluctuating hormone levels in Menopause āPerimenopauseā refers to the several years before menopause when a woman may begin experiencing the first signs of her menopausal transition. First Symptom Of Menopause, Early Menopause Symptom | The First If youāve been trying and havenāt been able to conceive, this too can be an early sign of menopause. The first symptom of menopause that you experience may Menopause 101 - What Are The Signs Of Menopause? Menopause changes levels of estrogen and progesterone can cause a variety of symptoms. One of the first signs is a change in your periods. Is This Perimenopause? Perimenopause is the ten to fifteen years before menopause occurs. Changes in your period are likely one of the first signs that will signal you that Menopause - Signs and Symptoms - womenshealthchannel In some women, vaginal dryness is the first sign of menopause. In one study about 20% of the women reported experiencing vaginal dryness, and 15% found it First Symptoms Of Menopause Article Women need to be aware of the first signs of menopause because these signs can indicate to a woman that she is losing the important hormone, estrogen. First Symptoms of Menopause and First Signs of Menopause What are my first symptoms of menopause, first signs of menopause, first menopause sign, first menopause symptom, first signs of menopause constipation and Early Menopause Symptoms & First Symptoms of Menopause Nearly every woman in her 30's or 40's will wonder if what she is experiencing may be early menopause symptoms. The first symptoms of menopause are signs |
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