Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Association between alterations in body composition and bone loss BODY. COMPOSITION AND BONE LOSS IN EARLY MENOPAUSE. C. Brot. L.B. Jeusen, O.H. Serensen. Osteoporosis Research Center,. Copenhagen Municipal Hospital Effect of body mass index, body composition, age and menopause on Page 1. Page 2. Medical Menopause Increases Upper-Body Fat and Decreases Lean Body To investigate the effect of medically induced menopause on body composition and fat distribution, Japanese researchers studied 15 women who were given a eMJA: Nutrition and physical activity needs of women aged 40 and over Prospective studies of body composition during menopause show increasing total and central abdominal fat and decreasing lean muscle tissue.1,2 However, Exercise Plus Isoflavones May Improve Body Composition in "Menopause is associated with alterations in body composition, such as a gain of fat mass (FM), essentially at the abdominal level, which increases Weight gain after menopause: Reverse the middle age spread Weight gain after menopause Á” Causes of weight gain and strategies to minimize weight When your body composition shifts to more fat and less muscle, Changes in body composition at menopause--age, lifestyle or Changes in body composition at menopause--age, lifestyle or hormone deficiency? Sorensen MB. Cardiovascular MR Unit, Royal Brompton Hospital, and Department Menopause - Fulltext: Volume 7(6) November 2000 p 419-420 Letters 1 These results, however, should not lead to the conclusion that menopause has no effect on body composition, and especially on body fat distribution, Maturitas : Effects of soy protein and resistance exercise on body 23 D. Goodman-Gruen and D. Kritz-Silverstein, Usual dietary isofalvone intake and body composition in postmenopausal women, Menopause 10 (2003), pp. Effects of gender, body composition, and menopause on plasma Effects of gender, body composition, and menopause on plasma concentrations of leptin. M Rosenbaum, M Nicolson, J Hirsch, SB Heymsfield, D Gallagher, CUHK SIR: Changes of body composition at menopause: a prospective Title:, Changes of body composition at menopause: a prospective study in Chinese women. Authors:, HO Suzanne Sutying (È™³È»ªÈ¸š) CHAN Sieu Gaen Blackwell Synergy - Ann NY Acad Sci, Volume 904 IN VIVO BODY To clarify the effect of the menopause transition on body fat distribution, we measured total and regional body composition and abdominal fat distribution Postgraduate Medicine: Weight gain during menopause To understand the epidemiology of weight change, changes in body fat distribution, and body composition during menopause; To become aware of the IngentaConnect Changes in body composition at menopause-age Changes in body composition at menopauseÁ”age, lifestyle or hormone deficiency? Author: Sö¸rensen M.B.1. Source: Journal of the British Menopause Society, Changes in Energy Balance and Body Composition at Menopause: A Objective: To describe the effects of menopause on resting metabolic rate, body composition, fat distribution, physical activity during leisure time, EFFECTS OF GENDER, BODY COMPOSITION, AND MENOPAUSE ON PLASMA in U.S.A.. EFFECTS OF GENDER, BODY COMPOSITION,. AND MENOPAUSE. ON PLASMA. CONCENTRATIONS. OF LEPTIN. MICHAEL ROSENBAUM*,. MARGERY NICOLSON, JULES HIRSCH, Effect of menopausal status on body composition and abdominal fat OBJECTIVE: Preliminary studies suggest that the menopause transition is associated with deleterious changes in body composition and abdominal fat Body composition and muscle performance during menopause and Some studies clearly suggest that HRT counteracts menopause-related changes in body composition whereas others fail to show any difference between Body Composition It is increasingly well appreciated that body composition and body composition .. therapy prevents central distribution of body fat after menopause. |
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