Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Age Of Menopause Dictated Largely By Genes The age at which a woman reaches menopause is 85% genetically determined New Research Shows That The Seasons May Be Involved In Onset Of Menopause (Jun. Age at menopause predicts age at onset of Parkinson's disease Linear regression analyses showed a significant correlation between age at PD onset and age at menopause(P= 0. 003), between age at PD onset and fertile Ask A Scientist - Females, ovulation, and menopause Over time, oocytes will continue to be lost; thus, it is likely that birth control and pregnancy will not substantially affect the age of onset of menopause Smoking, Obesity May Promote Early Menopause-Miscellaneous Obesity When the women were assessed at age 43, smoking was associated with a mean of 1.6 years earlier menopause onset. Similarly, each 20 mg/dL increased in Menopause Symptoms, What is it? When does it happen? Power Surge For most women, natural menopause occurs between the ages of 45 and 55, with the average age of onset being 51.4 years of age. In rare instances, menopause IngentaConnect Age at onset of dementia and age of menopause in The average age of menopause in 42 subjects (44.7 years) was younger than in the general population. The age at onset of dementia correlated with the age of Do Cardiac Risk Factors Influence Age at Menopause? - Journal was associated with earlier menopause onset (for each 1% increase in risk score, However, an editorialist points out that age of menopause remains Maturitas : On adaptive onset hypothesis (AOH) of menopause Most (but not all) studies have suggested that parity is linked with age at onset of menopause: nulliparous women have an early menopause 2, 3, 4, Parity, Number of Pregnancies, and the Age of Onset of Alzheimer's The association between late menopause and age at onset of AD (which might represent a marker of the rate of cognitive decline) has been shown by several Menopause Menopause can occur anytime after the age of 35, but the typical age of onset is in the late 40s. A womanâ™s ovaries, the organs that produce eggs, Maturitas : An overview of age of onset of menopause in northern 21 M.S. Henriquez, N.M.C. Rodriquez and L.J.M. Canal et al., Age of menopause onset in Canary Islands women, Rev Sanid Hig Publica (Madr) 68 (1994), pp. Menopause symptoms, diagnosis, and treatment on MedicineNet.com The age at which a woman starts having menstrual periods is also not related to the age of menopause onset. Most women reach menopause between the ages of Alternative Medicine - Herbs, Yoga and Nutritional Supplements On average, menopause occurs at age 51, but like the beginning of menstruation in Some researchers speculate that the timing of menopause onset may be Age at the Onset of Menopause at Menopause Insight Menopause Insight is an interesting and informative guide designed to educate people about the effects of menopause. Review the excellent information we Hormone Therapy Given Closer to Menopause Onset Is Safest Hormone Therapy Given Closer to Menopause Onset Is Safest CME/CE . Age at menopause was defined by the age of last menstrual bleeding, Age at onset of menopause Age of menarche related to age of menopause? Dr. Kisch generalises on the relation between the age of onset of menstruation and the age at which it ceases. Health 24 - Menopause, Age and menopause The later onset of menopause? Last updated: Tuesday, May 15, 2007. It has been known that the age of menarche (having the first menstrual period) is Menopause Based on cross sectional studies, the median age at menopause has been 70% experience oligomenorrhea and 12% have regular cycles to the onset of Average Age of Menopause Onset and What Age is Menopause Average age of menopause, menopause defined, age and first signs of menopause, what age is menopause, average age of menopause, average age of menopause |
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